ABSTRACT
Background: To know the various causes of lymphadenopathy in children and to know the usefulness of FNAC in diagnosis of various causes of lymphadenopathy.Methods: Children less than 12 years with significant lymphadenopathy (lymphadenopathy of >1 cm in cervical, axillary and >1.5 cm in inguinal region) were included.Results: A total of 50 children were enrolled in the study. The incidence of lymphadenopathy was more common in the age group of 4-8 year during the lymphoid phase with male preponderance of all the causes infections especially tuberculosis was the major cause of lymphadenopathy which is totally preventable by giving BCG vaccination. The sensitivity of FNAC in the present study was 71.3%. In 3 cases FNAC 69 was not done because peripheral smear examination revealed that the patients are suffering from acute lymphoblastic leukemia.Conclusions: FNAC is a simple bed side investigation though traumatic is of immense value for diagnosing various cases. Even though it may not be a replacement for lymphnode biopsy, it is preferred as a first line investigation because of its simple procedure.
ABSTRACT
Oxidative stress is involved in the pathophysiology of diabetes mellitus. In the present study, 68 patients with type 2 diabetes mellitus and 31 clinically healthy individuals were evaluated. The patients were divided into two groups. Group 1 included 29 patients without diabetic complications and group 2 consisted of 39 patients with diabetic complications. Erythrocyte glutathione, superoxide dismutase, and thiobarbituric acid-reactive substance levels as well as plasma antioxidant vitamins C and E, and serum total glutathione-S-transferase, ceruloplasmin, and protein thiols were estimated by using spectro-photometer. A significant decrease of erythrocyte glutathione was observed in group 1 when compared with the controls. Thiols decreased in group 2. An increase in glutathione-S-transferase, ceruloplasmin, superoxide dismutase, and vitamins C and E levels was noted in patients with diabetes mellitus. Thiobarbituric acid-reactive substance levels decreased in group 1 but increased in group 2 when compared with the controls. In the present study, tendency of most of the antioxidants to rise in diabetes could probably be due to an adaptive response to the pro-oxidant milieu of the diabetic state. Hence, we suggest that supplementation with dietary antioxidants especially antioxidant vitamins accompanied by change in lifestyle might help to reduce damage brought about by free radical toxicity in diabetes mellitus